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Your Position: ホーム > FcRn (FCGRT & B2M)

FcRn (FCGRT & B2M)

概要

Name:IgG receptor FcRn large subunit p51
Target Synonym:Alpha-Chain,FcRn,Major Histocompatibility Complex Class I-Like Fc Receptor,Immunoglobulin Receptor, Intestinal, Heavy Chain,Neonatal Fc-Receptor For Ig,FcRn Alpha Chain,FCGRT,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,Fc Fragment Of IgG Receptor And Transporter,Transmembrane Alpha Chain Of The Neonatal Receptor,Fc Fragment Of IgG, Receptor, Transporter, Alpha,IgG receptor FcRn large subunit p51,Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Recepto
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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製造番号 種類 製品説明 構造 純度 特徴
FRT-01 Human Human FcRn binding Kit (TR-FRET)
CHEK-ATP132 Human HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line
FCM-H5283 Human Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified)
FCM-H5283-structure
FCM-H5283-sds
FCM-C82W9 Canine Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified)
FCM-C82W9-structure
FCM-C82W9-sds
CHEK-ATP079 Human HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line
FCM-C52W8 Canine Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)
FCM-C52W8-structure
FCM-C52W8-sds
FCM-R82W6 Rabbit Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified)
FCM-R82W6-structure
FCM-R82W6-sds
FCM-R52W5 Rabbit Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)
FCM-R52W5-structure
FCM-R52W5-sds
FCM-H82W7 Human Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCM-H82W7-structure
FCM-H82W7-sds
FCM-M52W8 Mouse Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified)
FCM-M52W8-structure
FCM-M52W8-sds
FCM-M82W5 Mouse Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & BLI verified)
FCM-M82W5-structure
FCM-M82W5-sds
FCM-C52W9 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified)
FCM-C52W9-structure
FCM-C52W9-sds
FCM-C82W3 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCM-C82W3-structure
FCM-C82W3-sds
FCN-H52W7 Human Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & BLI & MALS verified)
FCN-H52W7-structure
FCN-H52W7-sds
FCN-B82W3 Bovine Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCN-B82W3-structure
FCN-B82W3-sds
FCN-F82W3 Feline Biotinylated Feline FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCN-F82W3-structure
FCN-F82W3-sds
FCM-P5280 Porcine Porcine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified)
FCM-P5280-structure
FCM-P5280-sds
FCM-C82W5 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Strep II Tag (HPLC&SPR&BLI verified)
FCM-C82W5-structure
FCM-C82W5-sds
FCM-C82W5-hplc
FCM-R82W7 Rat Biotinylated Rat FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (MALS & SPR verified)
FCM-R82W7-structure
FCM-R82W7-sds
FCM-M82W6 Mouse Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Twin-Strep Tag (MALS & BLI-verified)
FCM-M82W6-structure
FCM-M82W6-sds
FCM-H82W4 Human Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (SPR & BLI & HPLC verified)
FCM-H82W4-structure
FCM-H82W4-sds
FCM-H82W4-hplc
FCM-M52W2 Mouse Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Twin-Strep Tag (MALS & BLI verified)
FCM-M52W2-structure
FCM-M52W2-sds
FCM-H8286 Human Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, ultra sensitivity (primary amine labeling) (HPLC & SPR verified)
FCM-H8286-structure
FCM-H8286-sds
FCM-H8286-hplc
FCM-R5287 Rat Rat FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified)
FCM-R5287-structure
FCM-R5287-sds
FCM-C5284 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & MALS verified)
FCM-C5284-structure
FCM-C5284-sds
FCM-H5286 Human Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & HPLC-verified)
FCM-H5286-structure
FCM-H5286-sds
FCM-H5286-hplc
ACRO Quality

生物活性データの一部

CHEK-ATP132-Cell-based assay
FcRn (FCGRT & B2M) FACS

Fig. FACS analysis of FcRn (FCGRT & B2M) on HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line.
HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line was red line, negative control HEK293 cells was grey line(QC tested).

Protocol
CHEK-ATP079-Cell-based assay
FcRn (FCGRT & B2M) FACS

FACS analysis of FcRn (FCGRT & B2M) on HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line.
FACS assay shows that FITC-Labeled Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag (Cat. No. IG1-HF2H3) can bind to HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line. HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line was red line, negative control HEK293 cells was grey line(QC tested).

Protocol
FCM-H5283-SPR
FcRn (FCGRT & B2M) SPR

Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F), His Tag (Cat. No. IG1-H52H8) immobilized on CM4 Chip can bind Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (Cat. No. FCM-H5283) with an affinity constant of 23.8 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
FCM-H5283-SPR
FcRn (FCGRT & B2M) SPR

Herceptin immobilized on CM4 Chip can bind Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (Cat. No. FCM-H5283) with an affinity constant of 2.67 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

カスタマーレビュー

FcRn (FCGRT & B2M) Molecule Synonym Name

FcRn,FCGRT & B2M

FcRn (FCGRT & B2M) Molecule Background

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

FcRn (FCGRT & B2M) References

公開薬物情報

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Efgartigimod alfa ARGX-113; EFG PH20; EFG PH20 SC; PH20 SC Approved Argenx Se VYVGART HYTRULO, Vyvgart, 卫伟迦, VYVGART United States Myasthenia Gravis Argenx BV 2021-12-17 Postural Orthostatic Tachycardia Syndrome; Tachycardia; Pemphigus; Nephrotic Syndrome; Muscular Diseases; Guillain-Barre Syndrome; Thrombocytopenia; Pemphigoid, Bullous; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Lupus Nephritis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Autoimmune Diseases; Polyneuropathies; Nephrosis; Dermatomyositis; Myositis; Polymyositis; Myasthenia Gravis; Purpura, Thrombocytopenic, Idiopathic Details
Rozanolixizumab UCB-7665 Approved Ucb Sa RYSTIGGO United States Myasthenia Gravis Ucb Inc 2023-06-27 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Myasthenia Gravis; Thrombocytopenia; Glioma; Fibromyalgia; Encephalitis Details
Efgartigimod alfa/Hyaluronidase Approved Argenx BV VYVDURA, VYVGART HYTRULO United States Myasthenia Gravis Argenx BV 2023-06-20 Myasthenia Gravis Details
Efgartigimod alfa ARGX-113; EFG PH20; EFG PH20 SC; PH20 SC Approved Argenx Se VYVGART HYTRULO, Vyvgart, 卫伟迦, VYVGART United States Myasthenia Gravis Argenx BV 2021-12-17 Postural Orthostatic Tachycardia Syndrome; Tachycardia; Pemphigus; Nephrotic Syndrome; Muscular Diseases; Guillain-Barre Syndrome; Thrombocytopenia; Pemphigoid, Bullous; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Lupus Nephritis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Autoimmune Diseases; Polyneuropathies; Nephrosis; Dermatomyositis; Myositis; Polymyositis; Myasthenia Gravis; Purpura, Thrombocytopenic, Idiopathic Details
Rozanolixizumab UCB-7665 Approved Ucb Sa RYSTIGGO United States Myasthenia Gravis Ucb Inc 2023-06-27 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Myasthenia Gravis; Thrombocytopenia; Glioma; Fibromyalgia; Encephalitis Details
Efgartigimod alfa/Hyaluronidase Approved Argenx BV VYVDURA, VYVGART HYTRULO United States Myasthenia Gravis Argenx BV 2023-06-20 Myasthenia Gravis Details

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Nipocalimab M-281; JNJ-80202135 Phase 3 Clinical Momenta Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Myasthenia Gravis; Hemolysis; Myositis; Arthritis, Rheumatoid; Sjogren's Syndrome; Lupus Nephritis; Anemia, Hemolytic, Autoimmune; Lupus Erythematosus, Systemic; Pemphigoid, Bullous Details
IMVT-1402 HL-161 ANS; IMVT-1402 Phase 1 Clinical Immunovant Sciences Gmbh, HanAll Biopharma Co Ltd Autoimmune Diseases Details
Nipocalimab M-281; JNJ-80202135 Phase 3 Clinical Momenta Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Myasthenia Gravis; Hemolysis; Myositis; Arthritis, Rheumatoid; Sjogren's Syndrome; Lupus Nephritis; Anemia, Hemolytic, Autoimmune; Lupus Erythematosus, Systemic; Pemphigoid, Bullous Details
IMVT-1402 HL-161 ANS; IMVT-1402 Phase 1 Clinical Immunovant Sciences Gmbh, HanAll Biopharma Co Ltd Autoimmune Diseases Details

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